刘哲教授，男，1977年出生，山东省“泰山学者海外特聘专家”，曲阜师范大学“抗癌药物开发及诊疗应用研究所”所长，化学学科研究中心副主任，山东师范大学博士生导师，济南大学客座教授，博士后指导教师，英国皇家化学会会员，国际生物无机化学会会员，中国化学会会员。承担国家自然科学基金、省泰山学者基金等多项基金。多次受邀为ACS、RSC、Elsevier、Springer等国际出版社旗下的众多刊物审稿。

2008至2011年获WPRS奖学金，师从英国皇家科学院院士Peter J. Sadler教授，在英国华威大学获得化学专业博士学位；2012-2015年分别在英国华威大学和瑞士巴塞尔大学从事研究工作，2015年以“泰山学者海外特聘专家”加盟曲阜师范大学，并任“抗癌药物开发及诊疗应用研究所”所长。 主要研究领域为生物无机化学，研究方向包括：金属配合物药物化学；新型金属抗癌药物的设计、开发及作用机理研究；新型纳米材料设计、合成及肿瘤诊疗一体化研究；金属配合物在生物催化及催化聚合中的应用等。

目前在金属化合物抗癌和生物催化领域均取得了一系列开拓性研究成果，打破了科学界对铱化合物药用局限的传统观念。对代表性铱化合物（ZL105）开展的抗癌和生物催化研究，已被美国Science Daily和英国BBC连续报道。

Science Daily报道：http://www.sciencedaily.com/releases/2014/03/140325102705.htm

BBC报道：http://www.bbc.com/news/uk-england-coventry-warwickshire-26837963

代表性论文包括Acc. Chem. Res.（IF = 20.833，他引120余次）1篇, Angew. Chem. Int. Ed.（IF = 13.734，一篇被评为VIP文章）4篇, J. Med. Chem.（IF = 5.614，他引120余次）1篇。海外期间作为第一完成人参与国际科研项目四项，其中重大项目两项（European Research Council, Swiss National Science Foundation，科研经费156.5万欧元和25万瑞士法郎）。

设计开发的金属铱抗癌化合物具有广谱、高效、低毒的特点，显示了不同于临床铂类药物的新奇抗癌机理，能通过DNA双重作用机制和氧化应激机制(ROS)等多种作用方式杀死癌细胞，并在正常细胞和癌细胞之间有较高的选择性。现已设计开发了大批具有超强抗癌活性（比临床抗癌药物顺铂高十倍）和广谱抗癌效果的铱化合物，对肺癌、乳腺癌、卵巢癌、白血病、黑色素瘤等均有特殊疗效，且与临床铂类药物无交叉耐药性，获得了中国和欧洲工业界的广泛兴趣，已申请国际专利1项，极具市场开发潜力。

另外，首次报道了金属化合物和辅酶NADH之间的氢负离子转移现象，并成功开发了铱-NADH催化体系，该催化系统在生物条件下已成功应用于氢气、活性氧产生，以及生物醌催化还原等领域，对于金属化合物抗癌机理研究、活性氧产生机制及生物催化等领域都具有重大意义，展示了其作为生物催化药物的光明前景。

代表性论文

Liu, Z.; Lebrun, V.; Kitanosono, T.; Mallin, H.; Köhler, V.; Häussinger, D.; Hilvert, D.; Kobayashi, S.; Ward, T. R. Upregulation of an Artificial Zymogen by Proteolysis. Angew. Chem. Int. Ed. 2016, 55, 11587–11590. (Impact Factor：11.709)

Liu, Z.; Romero-Canelón, I.; Qamar, B.; Hearn, J. M.; Habtemariam, A.; Barry, N. P. E.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. The Potent Oxidant Anticancer Activity of Organoiridium Catalysts, Angew. Chem. Int. Ed. 2014, 53, 3941-3946. (VIP，Impact Factor：13.734，reported by BBC and Science Daily)

Liu, Z.; Sadler, P. J. Organoiridium Complexes: Anticancer Agents and Catalysts. Acc. Chem. Res. 2014, 47, 1174-1185. (Impact Factor：20.833)

Liu, Z.; Deeth, R. J.; Butler, J. S.; Habtemariam, A.; Newton, M. E.; Sadler, P. J. Reduction of Quinones by NADH Catalyzed by Organoiridium Complexes. Angew. Chem., Int. Ed. 2013, 52, 4194-4197. (Impact Factor：13.734)

Betanzos-Lara, S.; Liu, Z. (equal first author); Habtemariam, A.; Pizarro, A. M.; Qamar, B.; Sadler, P. J. Organometallic ruthenium and iridium transfer hydrogenation catalysts using coenzyme NADH as a cofactor. Angew. Chem., Int. Ed. 2012, 51, 3897-3900. (Impact Factor：13.734)

Liu, Z.; Romero-Canelón, I.; Habtemariam, A.; Clarkson, G. J.; Sadler, P. J. Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C^N-Chelated and Pyridine Ligands. Organometallics 2014, 33, 5324-5333. (Impact Factor：4.145)

Liu, Z.; Sadler, P. J. Formation of Glutathione Sulfenate and Sulfinate Complexes by an Organoiridium(III) Anticancer Complex. Inorg. Chem. Front. 2014, 1, 668-672. (Impact Factor：4.532)

Liu, Z.; Habtemariam, A.; Pizarro, A. M.; Fletcher, S. A.; Kisova, A.; Vrana, O.; Salassa, L.; Bruijnincx, P. C. A.; Clarkson, G. J.; Brabec, V.; Sadler, P. J. Organometallic half-sandwich iridium anticancer complexes. J. Med. Chem. 2011, 54, 3011-3026. (Impact Factor：5.614)

Liu, Z.; Salassa, L.; Habtemariam, A.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorg. Chem. 2011, 50, 5777-5783. (Impact Factor：4.593)

Liu, Z.; Habtemariam, A.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics 2011, 30, 4702-4710. (Impact Factor：4.145)

Gong, P.; Wang, J.; Hou, K.; Yang, Z.; Wang, Z.; Liu, Z.; Han, X.; Yang, S. Small but strong: The influence of fluorine atoms on formation and performance of graphene quantum dots using a gradient F-sacrifice strategy. Carbon 2017, 112, 63-71.（Impact Factor：6.189）

Du, J.; Liu, J.; Gong, P.; Tian, M.; Sun, L.; Ji, S.; Zhang, L.; Liu, Z.* Construction of a novel fluorinated graphene-based magnetic nanocomposite and its application in cancer photo-chemotherapy. Materials Letters. 2017

Guo, L.; Jing, X.; Xiong, S.; Liu, W.; Liu, Y.; Liu, Z.; Chen, C. Influences of Alkyl and Aryl Substituents on Iminopyridine Fe(II)- and Co(II)-Catalyzed Isoprene Polymerization. Polymers 2016, 8, 389. (Impact Factor：3.043)

Fu, Y.; Sanchez-Cano, C.; Soni, R.; Romero-Canelon, I.; Hearn, J. M.; Liu, Z.; Wills, M.; Sadler, P. J. The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Trans. 2016, 45, 8367-8378. (Impact Factor：4.177)

Novohradsky, V.; Zerzankova, L.; Stepankova, J.; Kisova, A.; Kostrhunova, H.; Liu, Z.; Sadler, P. J.; Kasparkova, J.; Brabec, V. A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex. Metallomics 2014, 6, 1491-1501. (Impact Factor：4.099)

Novohradsky, V.; Liu, Z.; Vojtiskova, M.; Sadler, P. J.; Brabec, V.; Kasparkova, J. Mechanism of Cellular Accumulation of an Iridium(III) Pentamethylcyclopentadienyl Anticancer Complex Containing a C,N-Chelating Ligand. Metallomics 2014, 6, 682-690. (Impact Factor：4.099)

Hearn, J. M.; Romero-Canelón, I.; Qamar, B.; Liu, Z.; Hands-Portman, I.; Sadler, P. J. Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis. ACS Chem. Biol. 2013, 8, 1335-1343. (Impact Factor：5.442)

Qi, Y; Liu, Z.; Li, H.; Sadler, P. J.; O’Connor, P. B. Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation. Rapid Commun. Mass Spectrom. 2013, 27, 2028-2032. (Impact Factor：2.509)

国际专利（已获得英国、美国、欧洲授权）

Habtemariam, A.; Liu, Z.; Soldevila, J. J.; Pizarro, A. M.; Sadler, P. J. Novel Iridium/Rhodium Anti-Cancer Compounds, PCT Int. Appl. 2011, 88p, WO 2011/148124 A1.

参加会议

The 8th Asian Biological Inorganic Chemistry Conference, Auckland, New Zealand, 2016, Oral lecture.

The 13th China Biological Inorganic Chemistry Conference, Shanghai, China, 2016, Oral lecture.

The 30th Chinese Chemical Society Congress, Dalian, China, 2016, Invited lecture.

Sadler's Symposium on Metals in Life Processes，Sun Yat-sen University，Guangzhou, China, 2015. Invited lecture.

The 17th International Conference on Biological Inorganic Chemistry (ICBIC17)，Beijing, China, 2015. Oral lecture.

The 12th International Symposium on Applied Bioinorganic Chemistry，Sun Yat-sen University, Guangzhou, China, 2013. Oral lecture.

Gordon Research Conference on Metals in Biology, Ventura, CA, USA, 2013. Poster presentation.

COST Chemistry D39 working group meeting: "Analysis of DNA Damage by Metal-Based Compounds", Brno, Czech Republic, 2011. Oral lecture.

University of Warwick Chemistry Postgraduate Research Symposium, Coventry, United Kingdom, 2011. Oral lecture.

5th International Symposium on Bioorganometallic Chemistry, Ruhr-University Bochum, Germany, 2010. Poster presentation.

University of Warwick Chemistry Postgraduate Research Symposium, Coventry, United Kingdom, 2010. Poster presentation.