研究领域

研究领域及方向

主要研究领域涉及生物无机化学、有机化学、生物医药以及材料化学，以化学合成为基础，我们开展了一系列抗癌领域的前沿学术研究，具体研究方向：

金属配合物药物化学
新型金属抗癌药物的设计、开发及作用机理研究
新型纳米材料设计、合成及肿瘤诊疗一体化研究
金属配合物在生物催化及催化聚合中的应用

代表性成果

1. 抗癌药物设计

Liu, Z.; Sadler, P. J. Organoiridium Complexes: Anticancer Agents and Catalysts. Acc. Chem. Res. 2014, 47, 1174-1185. (Impact Factor：20.833)

2. 金属抗癌药物作用机理研究

Liu, Z.; Sadler, P. J. Organoiridium Complexes: Anticancer Agents and Catalysts. Acc. Chem. Res. 2014, 47, 1174-1185. (Impact Factor：20.833)

Liu, Z.; Romero-Canelón, I.; Qamar, B.; Hearn, J. M.; Habtemariam, A.; Barry, N. P. E.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. The Potent Oxidant Anticancer Activity of Organoiridium Catalysts, Angew. Chem. Int. Ed. 2014, 53, 3941-3946. (VIP，Impact Factor：13.734，reported by BBC and Science Daily)

Liu, Z.; Romero-Canelón, I.; Habtemariam, A.; Clarkson, G. J.; Sadler, P. J. Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C^N-Chelated and Pyridine Ligands. Organometallics 2014, 33, 5324-5333. (Impact Factor：4.145)

Liu, Z.; Sadler, P. J. Formation of Glutathione Sulfenate and Sulfinate Complexes by an Organoiridium(III) Anticancer Complex. Inorg. Chem. Front. 2014, 1, 668-672. (Impact Factor：4.532)

Liu, Z.; Habtemariam, A.; Pizarro, A. M.; Fletcher, S. A.; Kisova, A.; Vrana, O.; Salassa, L.; Bruijnincx, P. C. A.; Clarkson, G. J.; Brabec, V.; Sadler, P. J. Organometallic half-sandwich iridium anticancer complexes. J. Med. Chem. 2011, 54, 3011-3026. (Impact Factor：5.614)

Liu, Z.; Salassa, L.; Habtemariam, A.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorg. Chem. 2011, 50, 5777-5783. (Impact Factor：4.593)

Liu, Z.; Habtemariam, A.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics 2011, 30, 4702-4710. (Impact Factor：4.145)

Novohradsky, V.; Liu, Z.; Vojtiskova, M.; Sadler, P. J.; Brabec, V.; Kasparkova, J. Mechanism of Cellular Accumulation of an Iridium(III) Pentamethylcyclopentadienyl Anticancer Complex Containing a C,N-Chelating Ligand. Metallomics 2014, 6, 682-690. (Impact Factor：4.099)

Hearn, J. M.; Romero-Canelón, I.; Qamar, B.; Liu, Z.; Hands-Portman, I.; Sadler, P. J. Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis. ACS Chem. Biol. 2013, 8, 1335-1343. (Impact Factor：5.442)

3. 生物催化体系

Upregulation of Artificial Metallo-Enzymes

(a) Chemical structure of NADH and NAD+. (b) Ir catalysts utilized for NAD+/NADH conversion. (c) Proposed mechanism for catalytic hydride transfer from NADH to Ir–H2O complexes.

(a) One- and two-electron reduction of a quinone leading to semiquinoneand hydroquinone, respectively. (b) Chemical structures of menadione and duroquinone. (c) EPR spectra of menadione (top) and duroquinone (down)radical anions. (d) Proposed mechanism for the catalytic reduction of duroquinone by NADH/Ir system.

Liu, Z.; Lebrun, V.; Kitanosono, T.; Mallin, H.; Köhler, V.; Häussinger, D.; Hilvert, D.; Kobayashi, S.; Ward, T. R. Upregulation of an Artificial Zymogen by Proteolysis. Angew. Chem. Int. Ed. 2016, 55, 11587–11590. (Impact Factor：11.709)

Liu, Z.; Sadler, P. J. Organoiridium Complexes: Anticancer Agents and Catalysts. Acc. Chem. Res. 2014, 47, 1174-1185. (Impact Factor：20.833)

Liu, Z.; Deeth, R. J.; Butler, J. S.; Habtemariam, A.; Newton, M. E.; Sadler, P. J. Reduction of Quinones by NADH Catalyzed by Organoiridium Complexes. Angew. Chem., Int. Ed. 2013, 52, 4194-4197. (Impact Factor：13.734)

Betanzos-Lara, S.; Liu, Z. (并列一作); Habtemariam, A.; Pizarro, A. M.; Qamar, B.; Sadler, P. J. Organometallic ruthenium and iridium transfer hydrogenation catalysts using coenzyme NADH as a cofactor. Angew. Chem., Int. Ed. 2012, 51, 3897-3900. (Impact Factor：13.734)

4.石墨烯纳米诊疗材料

Du, J.; Liu, J.; Gong, P.; Tian, M.; Sun, L.; Ji, S.; Zhang, L.; Liu, Z.* Construction of a novel fluorinated graphene-based magnetic nanocomposite and its application in cancer photo-chemotherapy. Mater. Lett. 2017